DetoxFungiV1, Main, Exploration, bibRecord, 000080

Role of Glutathione in Cancer: From Mechanisms to Therapies.

Identifieur interne : 000080 ( Main/Exploration ); précédent : 000079; suivant : 000081

Role of Glutathione in Cancer: From Mechanisms to Therapies.

Auteurs : Luke Kennedy [Canada] ; Jagdeep K. Sandhu [Canada] ; Mary-Ellen Harper [Canada] ; Miroslava Cuperlovic-Culf [Canada]

Source :

Biomolecules [ 2218-273X ] ; 2020.

RBID : pubmed:33050144

Abstract

Glutathione (GSH) is the most abundant non-protein thiol present at millimolar concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a regulator of cellular redox state protecting cells from damage caused by lipid peroxides, reactive oxygen and nitrogen species, and xenobiotics. Recent studies have highlighted the importance of GSH in key signal transduction reactions as a controller of cell differentiation, proliferation, apoptosis, ferroptosis and immune function. Molecular changes in the GSH antioxidant system and disturbances in GSH homeostasis have been implicated in tumor initiation, progression, and treatment response. Hence, GSH has both protective and pathogenic roles. Although in healthy cells it is crucial for the removal and detoxification of carcinogens, elevated GSH levels in tumor cells are associated with tumor progression and increased resistance to chemotherapeutic drugs. Recently, several novel therapies have been developed to target the GSH antioxidant system in tumors as a means for increased response and decreased drug resistance. In this comprehensive review we explore mechanisms of GSH functionalities and different therapeutic approaches that either target GSH directly, indirectly or use GSH-based prodrugs. Consideration is also given to the computational methods used to describe GSH related processes for in silico testing of treatment effects.

DOI: 10.3390/biom10101429
PubMed: 33050144
PubMed Central: PMC7600400

Affiliations:

Canada

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Glutathione (GSH) is the most abundant non-protein thiol present at millimolar concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a regulator of cellular redox state protecting cells from damage caused by lipid peroxides, reactive oxygen and nitrogen species, and xenobiotics. Recent studies have highlighted the importance of GSH in key signal transduction reactions as a controller of cell differentiation, proliferation, apoptosis, ferroptosis and immune function. Molecular changes in the GSH antioxidant system and disturbances in GSH homeostasis have been implicated in tumor initiation, progression, and treatment response. Hence, GSH has both protective and pathogenic roles. Although in healthy cells it is crucial for the removal and detoxification of carcinogens, elevated GSH levels in tumor cells are associated with tumor progression and increased resistance to chemotherapeutic drugs. Recently, several novel therapies have been developed to target the GSH antioxidant system in tumors as a means for increased response and decreased drug resistance. In this comprehensive review we explore mechanisms of GSH functionalities and different therapeutic approaches that either target GSH directly, indirectly or use GSH-based prodrugs. Consideration is also given to the computational methods used to describe GSH related processes for in silico testing of treatment effects.</div>
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<ArticleTitle>Role of Glutathione in Cancer: From Mechanisms to Therapies.</ArticleTitle>
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<Abstract><AbstractText>Glutathione (GSH) is the most abundant non-protein thiol present at millimolar concentrations in mammalian tissues. As an important intracellular antioxidant, it acts as a regulator of cellular redox state protecting cells from damage caused by lipid peroxides, reactive oxygen and nitrogen species, and xenobiotics. Recent studies have highlighted the importance of GSH in key signal transduction reactions as a controller of cell differentiation, proliferation, apoptosis, ferroptosis and immune function. Molecular changes in the GSH antioxidant system and disturbances in GSH homeostasis have been implicated in tumor initiation, progression, and treatment response. Hence, GSH has both protective and pathogenic roles. Although in healthy cells it is crucial for the removal and detoxification of carcinogens, elevated GSH levels in tumor cells are associated with tumor progression and increased resistance to chemotherapeutic drugs. Recently, several novel therapies have been developed to target the GSH antioxidant system in tumors as a means for increased response and decreased drug resistance. In this comprehensive review we explore mechanisms of GSH functionalities and different therapeutic approaches that either target GSH directly, indirectly or use GSH-based prodrugs. Consideration is also given to the computational methods used to describe GSH related processes for in silico testing of treatment effects.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kennedy</LastName>
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</ArticleIdList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12157-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25097261</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Lett. 2018 Oct 1;433:33-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29959055</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 2013 Feb 1;73(3):1245-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23221387</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biomarkers. 2012 Dec;17(8):671-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22900535</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Pharmacol. 2020 Mar 17;11:239</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32256352</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Interv Aging. 2018 Apr 26;13:757-772</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29731617</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2007 Jul 13;282(28):20416-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17452333</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Clin Oncol. 2017 Feb;6(2):139-153</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28357082</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11715-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9751731</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Physiol. 2020 Feb 10;82:103-126</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31730395</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 2014 Mar;68:315-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24374371</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2003 Sep 5;278(36):34286-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12819198</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2013 Jan;1833(1):80-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23069211</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2020 Jul;21(7):363-383</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32231263</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 2002 Jan 1;30(1):47-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11752250</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 1994 Sep 15;54(18):4833-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7915193</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Mol Genet. 2011 Dec 1;20(23):4605-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21890492</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20859-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19915149</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biofactors. 2019 Mar;45(2):152-168</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30561781</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Signal. 2020 Mar 24;13(624):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32209698</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nitric Oxide. 2014 Dec 1;43:17-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25153034</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2017 Jul 10;8:16018</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28691704</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Metab Eng. 2017 Sep;43(Pt B):103-112</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27825806</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2017 Nov;23(11):1362-1368</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28967920</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JCO Clin Cancer Inform. 2019 Feb;3:1-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30715927</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2018 May 18;293(20):7499-7507</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29282291</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Causes Control. 2009 Dec;20(10):2031-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19618282</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2017 Sep 21;67(6):962-973.e5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28918898</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Toxics. 2015 Jan 26;3(1):20-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29056650</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Hum Mol Genet. 2014 Mar 15;23(6):1453-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24163135</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 2016 Jan 1;76(1):7-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26729789</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pharmacol Rep. 2017 Jun;69(3):393-402</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28267640</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Drug Discov. 2013 Dec;12(12):931-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24287781</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 2011 Sep 15;51(6):1106-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21762777</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2019 May;25(5):850-860</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31068703</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Rep. 2016 Mar 15;14(10):2325-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26947075</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioinformatics. 2014 Aug 15;30(16):2386-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24790154</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2018 Jan 17;8(1):968</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29343855</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2008 May 2;320(5876):661-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18388260</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer Res. 2012 Sep;10(9):1203-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22878588</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Pharmacol. 2018 Oct 03;9:1120</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30337875</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biomark Res. 2019 Aug 6;7:16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31402980</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEMS Microbiol Lett. 2010 May;306(1):61-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20337710</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2017 Aug 16;8(45):80093-80102</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29108391</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Transl Med. 2020 Jul;8(14):905</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32793749</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Comput Biol. 2019 Jun 11;15(6):e1007053</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31185009</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antioxid Redox Signal. 2014 Aug 10;21(5):723-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24512276</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Adh Migr. 2012 May-Jun;6(3):193-202</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22568980</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2013 May;1830(5):3304-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23069719</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2012 Jun 8;287(24):20164-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22528487</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Metabolites. 2020 Mar 02;10(3):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32131411</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antioxid Redox Signal. 2019 Mar 10;30(8):1124-1143</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29634348</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Res. 2018 May;52(5):507-543</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29589770</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Stem Cell Reports. 2018 Feb 13;10(2):600-614</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29307581</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Expert Rev Anticancer Ther. 2010 Jul;10(7):997-1008</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20645688</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Biochem Sci. 2013 Dec;38(12):592-602</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24120033</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>iScience. 2020 Aug 21;23(8):101420</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32795915</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Cell Biol. 2019 Jun;97(3):270-289</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30427707</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem J. 2016 Apr 1;473(7):805-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27026395</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Cancer. 2016 May 15;138(10):2439-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26620126</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Adh Migr. 2007 Jul-Sep;1(3):156-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19262134</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2017 Jan;23(1):120-127</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27869804</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2009 Dec 4;284(49):34211-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19801663</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Aspects Med. 2009 Feb-Apr;30(1-2):13-28</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18786560</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antioxidants (Basel). 2019 Aug 16;8(8):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31426416</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ACS Omega. 2019 Jun 10;4(6):10070-10077</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31460099</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Theor Biol Med Model. 2008 Apr 28;5:8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18442411</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Chem Biol. 2016 Jul;12(7):482-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27159581</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogene. 2003 Oct 20;22(47):7369-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14576844</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Metab Rev. 2011 May;43(2):281-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21428694</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Commun Integr Biol. 2014 Jan 1;7(1):e28231</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24778765</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cell. 2009 Jun 26;34(6):663-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19560419</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7690-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7644478</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2016 Mar 10;164(6):1226-1232</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26967288</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2014 Jan 16;156(1-2):317-331</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24439385</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Chem Soc. 2018 Jun 20;140(24):7373-7376</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29799737</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Br J Cancer. 2020 Jan;122(2):168-181</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31819197</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2020 Apr 10;368(6487):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32273439</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Metastasis Rev. 2019 Jun;38(1-2):93-101</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30715644</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2956-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9501197</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 2015 Feb 27;589(5):621-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25637873</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Metabolites. 2018 Jan 11;8(1):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29324649</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2019 Apr 23;10(1):1841</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31015463</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Immunol. 2017 Sep 29;8:1239</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29033950</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogenesis. 2018 Jan 24;7(1):8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29362397</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2015 Nov 19;527(7578):329-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26524530</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Cell. 2015 Feb 9;27(2):211-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25620030</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Carcinogenesis. 2010 Apr;31(4):543-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19748928</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS Lett. 1997 Oct 13;416(1):15-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9369223</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Comput Struct Biotechnol J. 2016 Oct 27;15:8-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27872688</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Oncol. 2019 May 03;9:356</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31131261</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FEBS J. 2008 Aug;275(15):3959-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18616466</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2019 Dec;25(12):1822-1832</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31806905</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Redox Biol. 2020 May;32:101472</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32171726</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Cell Biol. 2016 May;18(5):572-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27088857</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Aspects Med. 2009 Feb-Apr;30(1-2):86-98</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18812186</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 1998 Oct 15;58(20):4515-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9788592</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2010 May 11;107(19):8788-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20421486</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 1993 Jan;14(1):85-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8384151</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 2018 May 20;120:204-216</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29578070</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Gene. 2019 Nov 30;719:144077</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31454540</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2015 Feb 26;160(5):963-976</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25723170</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2016 Aug 9;7(32):50814-50815</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27449104</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6491-6501</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32152094</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Res. 2010 Jul;44(7):721-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20528574</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2015 Nov 12;527(7577):186-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26466563</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Cell Biol. 2018 Jul 2;217(7):2291-2298</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29915025</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Cell. 2003 Mar;3(3):285-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12676586</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2013 Mar 22;288(12):8365-79</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23335511</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Dis. 2019 Apr 15;10(5):329</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30988280</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Surg Res. 2003 Jul;113(1):102-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12943817</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Oncol. 2010 Feb;36(2):491-500</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20043085</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antioxid Redox Signal. 2013 Nov 1;19(13):1539-605</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23397885</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EBioMedicine. 2019 May;43:98-106</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31126892</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2006 Aug;1758(8):994-1003</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16566894</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2012 Feb 10;287(7):4411-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22147701</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Clin Chem. 2016;74:103-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27117662</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Cancer. 2006 Jul;6(7):521-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16794635</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancers (Basel). 2020 Aug 06;12(8):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32781581</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2016 Apr 1;126(4):1208-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27035812</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Rep. 2017 Jul 5;20(1):224-235</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28683316</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Mol Cell Biol. 2005 Feb;6(2):150-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15688001</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2013 May;1830(5):3143-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22995213</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 2016 Nov;100:14-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27085844</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncol Ther. 2018 Dec;6(2):109-127</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32700032</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2009 Sep 3;461(7260):109-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19693011</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Redox Biol. 2020 Jan;28:101388</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31765890</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Cancer. 2019 Mar 1;18(1):32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30823926</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2020 Aug 3;:</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32747443</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogenesis. 2018 Jan 24;7(1):10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29362402</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biol Cybern. 1991;64(5):365-71</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2049412</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunol Rev. 2018 Jan;281(1):57-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29247996</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2019 Jul 16;51(1):27-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31315034</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Mol Med. 2014 Jul;20(7):385-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24703619</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>IUBMB Life. 2018 Jul;70(7):585-592</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29667297</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biomed Rep. 2014 Nov;2(6):831-834</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25279154</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Biol Interact. 2019 Feb 1;299:151-162</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30537466</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2013 May;1830(5):3267-88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23201197</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2019 Nov 27;9(1):17639</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31776385</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nitric Oxide. 2019 Jun 1;87:52-59</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30862477</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2012 Jun;18(6):883-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22635005</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ACS Nano. 2019 Jan 22;13(1):357-370</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30485068</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2019 Apr 19;9(1):6333</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31004119</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oxid Med Cell Longev. 2013;2013:972913</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23766865</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Cell Biol. 2015 Apr;33:8-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25305438</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Elife. 2016 Feb 27;5:e10250</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26920219</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2012 Jun 15;31(14):3169-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22705944</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2012;7(11):e48924</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23185284</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nano Converg. 2019 Jul 15;6(1):23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">31304563</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2002 Dec;3(12):1129-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12447370</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2015 Apr 2;520(7545):57-62</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25799988</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2014 May 15;5(9):2827-38</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24811539</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Immunol. 2020 Jan 21;10:3137</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32038644</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Annu Rev Cell Dev Biol. 2014;30:255-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25288114</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2016 Apr;1862(4):601-610</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26854735</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Physiol. 2017 Apr 12;8:217</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28446878</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Death Dis. 2020 Feb 3;11(2):88</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32015325</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Neural Transm (Vienna). 2010 Jan;117(1):1-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19680595</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Front Cell Dev Biol. 2017 Apr 26;5:43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28491867</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Biol Interact. 2020 Jun 1;324:109085</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32275922</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4600-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26229077</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Genes Dev. 2020 Apr 1;34(7-8):544-559</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32079653</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 2008 Aug 15;68(16):6661-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18701490</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Drug Des Devel Ther. 2018 Oct 23;12:3535-3547</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30425455</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2006 Jul 14;126(1):107-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16839880</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Metab. 2008 Sep;8(3):237-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18762024</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Lipid Res. 2016 Nov;57(11):1976-1986</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27009116</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2010 Dec 10;285(50):38832-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20923773</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Cancer. 2017 Nov;3(11):744-748</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29120749</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Signal Transduct Target Ther. 2020 Jun 30;5(1):108</Citation>
<ArticleIdList><ArticleId IdType="pubmed">32606298</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochim Biophys Acta. 2009 Nov;1790(11):1555-68</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19289149</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Adv Cancer Res. 2017;136:109-138</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29054415</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 2010 May 21;396(1):120-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20494123</ArticleId>
</ArticleIdList>
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<Reference><Citation>Eur J Surg Oncol. 2015 Feb;41(2):228-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25434328</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Free Radic Biol Med. 2017 Sep;110:19-30</Citation>
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<affiliations><list><country><li>Canada</li>
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<tree><country name="Canada"><noRegion><name sortKey="Kennedy, Luke" sort="Kennedy, Luke" uniqKey="Kennedy L" first="Luke" last="Kennedy">Luke Kennedy</name>
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<name sortKey="Cuperlovic Culf, Miroslava" sort="Cuperlovic Culf, Miroslava" uniqKey="Cuperlovic Culf M" first="Miroslava" last="Cuperlovic-Culf">Miroslava Cuperlovic-Culf</name>
<name sortKey="Cuperlovic Culf, Miroslava" sort="Cuperlovic Culf, Miroslava" uniqKey="Cuperlovic Culf M" first="Miroslava" last="Cuperlovic-Culf">Miroslava Cuperlovic-Culf</name>
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Role of Glutathione in Cancer: From Mechanisms to Therapies.

Role of Glutathione in Cancer: From Mechanisms to Therapies.

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Abstract

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